Detalhe da pesquisa
1.
Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment.
PLoS Comput Biol
; 19(10): e1011507, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37792732
2.
Population pharmacokinetics of sublingually administered tacrolimus in infants and young children with liver transplantation.
Br J Clin Pharmacol
; 89(3): 1115-1126, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36222177
3.
Relevance of primary lesion location, tumour heterogeneity and genetic mutation demonstrated through tumour growth inhibition and overall survival modelling in metastatic colorectal cancer.
Br J Clin Pharmacol
; 88(1): 166-177, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34087010
4.
A Quantitative Systems Pharmacology Model for the Key Interleukins Involved in Crohn's Disease.
J Pharmacol Exp Ther
; 372(3): 299-307, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31822515
5.
Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model.
Mol Genet Metab
; 128(3): 367-375, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30639045
6.
The circadian rhythm of corticosteroid-binding globulin has little impact on cortisol exposure after hydrocortisone dosing.
Clin Endocrinol (Oxf)
; 91(1): 33-40, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30868607
7.
Systematic Modeling and Design Evaluation of Unperturbed Tumor Dynamics in Xenografts.
J Pharmacol Exp Ther
; 366(1): 96-104, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29691287
8.
Population pharmacokinetic modelling of irosustat in postmenopausal women with oestrogen-receptor positive breast cancer incorporating non-linear red blood cell uptake.
Pharm Res
; 32(4): 1493-504, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25355461
9.
The fusion protein of IFN-α and apolipoprotein A-I crosses the blood-brain barrier by a saturable transport mechanism.
J Immunol
; 188(8): 3988-92, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22422884
10.
Modeling tumor response after combined administration of different immune-stimulatory agents.
J Pharmacol Exp Ther
; 346(3): 432-42, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23845890
11.
A physiologically based pharmacokinetic model for V937 oncolytic virus in mice.
Front Pharmacol
; 14: 1211452, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37771727
12.
Assessment of Clinical Response to V937 Oncolytic Virus After Intravenous or Intratumoral Administration Using Physiologically-Based Modeling.
Clin Pharmacol Ther
; 114(3): 623-632, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37170933
13.
Making use of modeling and simulations: Towards individualized tamoxifen therapy in breast cancerâ©.
Int J Clin Pharmacol Ther
; 55(8): 690-691, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-27641215
14.
Mechanistic modelling of enzyme-restoration effects of new recombinant liver-targeted proteins in acute intermittent porphyria.
Br J Pharmacol
; 179(14): 3815-3830, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35170015
15.
Mechanistic Modeling of a Novel Oncolytic Virus, V937, to Describe Viral Kinetic and Dynamic Processes Following Intratumoral and Intravenous Administration.
Front Pharmacol
; 12: 705443, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34366859
16.
A quantitative systems pharmacology model for acute viral hepatitis B.
Comput Struct Biotechnol J
; 19: 4997-5007, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34589180
17.
Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors.
Cancers (Basel)
; 13(20)2021 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34680196
18.
Gene therapy: a pharmacokinetic/pharmacodynamic modelling overview.
Pharm Res
; 27(8): 1487-97, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20387096
19.
Model-Informed Dose Selection for Xentuzumab, a Dual Insulin-Like Growth Factor-I/II-Neutralizing Antibody.
Clin Pharmacol Ther
; 107(3): 597-606, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31562819
20.
Machine Learning Analysis of Individual Tumor Lesions in Four Metastatic Colorectal Cancer Clinical Studies: Linking Tumor Heterogeneity to Overall Survival.
AAPS J
; 22(3): 58, 2020 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32185612